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pentobarbital will lower the extent or influence of atazanavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unidentified.pentobarbital will decrease the level or influence of naloxegol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Usage of naloxegol with potent CYP3A4 inducers just isn'